Its mechanism does not involve hormonal disruption, and clinical trials showed no sex-specific adverse effects
There is no direct evidence to suggest that MTHFR mutations significantly reduce life expectancy unless in the case of triple and quadruple mutation combinations
It has a long history of use as a botanical remedy dating back to the fourth century BCE, when ancient Greeks regarded it as a general medicinal herb.1 Since then, it has been used to treat an array of ailments, including but not limited to: Hepatitis Cirrhosis Jaundice Diabetes The active ingredient in milk thistle is silymarin, a group of flavonoids that comprises silybin, silychristin, isosilybin, and silidianin.11 Silymarin is whats known as a free radical scavenger, otherwise known as an antioxidant
Some mechanistic models propose that GLP-1s attenuate DMN activity specifically related to food rumination essentially reducing the brain's tendency to default toward food-related simulation when not otherwise occupied
Additionally, the pain or discomfort during defecation might result in incomplete evacuation, further contributing to constipation
